![]() The very first outbreak in the game's universe happened when the miners of one of Callisto's colonies found an alien creature in the ocean substrate of the moon, and while this life-form was killed, its carcass was ridden with larvae carrying the biophage pathogen. RELATED: The Callisto Protocol: Every Major Character Death and How They Die The Callisto Protocol's Miner Colony and the Origins of the Biophage Pathogen ![]() As for its origins, they stem from an event that occurred years prior to the game's present times, and they are tied to alien organisms found on the titular moon. Even the word biophage is descriptive of the virus, as it comes from bio and phage, which respectively mean "life" and "eater," and that's precisely what the pathogen does in the game, which is highlighted by The Callisto Protocol's enemy types. This is because everything is connected to the biophage pathogen and how it was discovered, in the beginning, and then later used as a bioweapon with the aim of recreating the original, unintended outbreak on Callisto. ![]() Understanding the events that ensued on Europa is critical to the plot, but so is the story behind Black Iron Prison's foundation and the original colony on Callisto. So, while The Callisto Protocol's ending sets up two sequels and a prequel that could expand this new universe a lot, the game also tries to answer burning questions that it asks since the beginning, such as what is happening on Callisto and what happened on Europa. ![]() The Callisto Protocol is an interesting case because it both seems to want to spawn other games to follow in its footsteps, and also deliver a story told in a self-contained environment where players get to learn the origins and form expectations for the future. PLEASE NOTE: This article contains MASSIVE Spoilers for The Callisto Protocol.
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